Five young men were rushed to UPMC Grove City around 12:15 a.m., Sunday morning after their car smashed into a guardrail on I-79 in Mercer County.
State police in Mercer County said the crash happened at the Clintonville Road overpass in Findley Township.
At least three of the men were ejected from the vehicle.
The driver, 20-year-old Dondi B. Kirby Jr. of Monroeville, suffered a major injury. Passenger Devantae J. Butler, also 20 and of Monroeville, received a moderate injury. The three other passengers had minor injuries.